Glucose Metabolism in the b-Cell

Glucose Metabolism in the b-Cell
Tutorial by: Richard Bertram

Metabolites as Signaling Molecules
Three Steps Involved in Glucose Metabolism
Glycolysis
Energy is Invested at the Beginning of Glycolysis
Energy is Generated During Second Step
What is the Mechanism for Glycolytic Oscillations?
Model Glycolytic Oscillations
Glycolytic Oscillations Occur Only for Moderate GK Rates
Citric Acid Cycle
Coenzymes are Produced by the Citric Acid Cycle
Anaplerosis and Cataplerosis
Anaplerosis Involving Pyruvate
Anaplerosis Involving Amino Acids
Cataplerosis of Citrate
Subway Analogy
Citric Acid Cycle
The Malate/Aspartate Shuttle
Oxidative Phosphorylation
Elements of Oxidative Phosphorylation
Mitochondrial Variables: NADH concentration
The NADH Equation
The ADP/ATP Equations
The Inner Membrane Potential Equation

Metabolism.ppt
http://www.math.fsu.edu/~bertram/presentations/workshops/MBI_07/Metabolism.ppt