Ion Channels in the Cardiovascular System in Health and Disease

Ion Channels in the Cardiovascular System in Health and Disease
Presentation by: William A. Coetzee

Hearts are Composed of Cells
The Cardiac Myocyte
Cells Have Membranes
Patch Clamping
Ion Channels - Gating
Inward Currents
Outward Currents
Ion Channels

* Na+ channels
* Ca2+ channels
* K+ channels
* Exchangers
* Pumps

Na+-Channels: Genetic Disorders
Na+ Channels - Pharmacology
Ca2+ Channels: Electrophysiology
Ca2+ Channel a-Subunits
Molecular Composition
Ca2+ Channel a-Subunits
Structural elements of function
Hyperkalemic periodic paralysis
Malignant hyperthermia
Functional Diversity of K+ Channels in the Heart
Voltage-activated K+ Channels
Inward Rectifier K+ Channels
Leak K+ Channels
Plateau (IKP) K+ channels
K+ Channels - Structure
K+ Channel Principal and Auxiliary Subunits
Voltage-gated K+ channels
Ca2+-activated K+ channels
Voltage-activated K+ Channels
Transient Outward K+ Channels
Delayed Rectifier Currents
Two Types of Delayed Rectifiers
Compounds Blocking Delayed Rectifiers
K+ Channel a-Subunits
Molecular determinants of gating
N-type inactivation
Kvb Subunits Accelerate Inactivation of Kv Channels
Enhanced Surface Expression
Kvb Subunits as Molecular Chaperones
3-Dimensional Structure of Kvb2
Kvb Confers Hypoxia-Sensitivity to Kv4 Channels
Identification of Frequenin as a Putative Kv4 b-subunit
Effects of Frequenin on Kv4.2 Currents
Delayed Rectifier K+ Channels
Molecular Composition
Voltage-activated K+ Channels Pharmacology
Mechanisms of Arrhythmias
Triggered Activity
Early Afterdepolarizations
Factors Promoting EADs
Inward Rectifier K+ Channels
Voltage-activated
Inward Rectifier K+ Channels
Electrophysiology
K+ Channel Principal Subunits
Voltage-gated K+ channels
Ca2+-activated K+ channels
K+ Channel Principal and Auxiliary Subunits
Voltage-gated K+ channels
Ca2+-activated K+ channels
Inward Rectifier K+ Channels
Genetic Disorders
Bartter’s syndrome
K+ Channel Principal and Auxiliary Subunits
Role of the KATP Channel
Secretory Mechanisms
Mechanism of Insulin Release
Glibenclamide Blocks KATP Channels

Ion Channels in the Cardiovascular System in Health and Disease.ppt