06 June 2012

Autism



Autism refers to a brain disorder that impairs the ability of a person to communicate.

Autism and Pervasive Developmental Disorders
Kenneth M. Rogers, MD, MSHS
Autism and Pervasive Developmental Disorders.ppt

Autism Spectrum Disorders
Deirdre Moore
Autism Spectrum Disorders.ppt

Autism
Eric Reiss
Autism.ppt

Autism and Related Disorders
Autism and Related Disorders.ppt

Treatments for Autism: An Overview of Model Programs
Fred R Volkmar MD
Treatments for Autism: An Overview of Model Programs.ppt

Autism
DominicaAUTISM.ppt

Autism Spectrum Disorders
By Kirsten Moreland and Kelsey Burns
Autism Spectrum Disorders.ppt

Understanding Students with Autism
Understanding Students with Autism.ppt

Screening and Diagnosis of Autism
P.A. Filipek, MD; P.J. Accardo, MD; S. Ashwal, MD; G.T. Baranek, PhD etal
Screening and Diagnosis of Autism.ppt

Practice Parameter: Medical Treatment of Infantile Spasms
Practice Parameter: Medical Treatment of Infantile Spasms.ppt

Infants at Risk of Autism
Infants at Risk of Autism.ppt

AUTISM & CHILDHOOD DISORDERS
Autism_Medicating Children.ppt

Overview Of Autism
Overview Of Autism.ppt

Childhood Autism Rating Scale (CARS)
Jennifer Connelly
Childhood Autism Rating Scale.ppt

Evaluating Treatments for Children with Autism
Evaluating Treatments for Children with Autism .ppt

Teaching Play to Children with Autism How Do Kids Learn to Play?
Teaching Play to Children with Autism.ppt

Understanding Autism
Sara Porter
Autism.ppt

Evaluating Treatments for Autism
Rachel Hoffman, M. A., Anne Shroyer, B.S
Evaluating Treatments for Autism.ppt

Autism Spectrum Disorder
Autism Spectrum Disorder.ppt

Autism
autism.ppt

WHAT IS Autism Spectrum Disorder?
Dr. Nancy J. Aguinaga
WHAT IS Autism Spectrum Disorder?.ppt

What is the cause of autism?
Sarah Marckstadt
What is the cause of autism?.ppt
600 free full text articles

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Juvenile Diabetes



Types of Diabetes
Type1_Diabetes.ppt

Diabetes Mellitus in Maltese Youth
Youthdiabetes.ppt

Juvenile Diabetes
Heaven Robinson
JuvenileDiabetesFinal1.ppt

Diabetes mellitus (DM)
Dr. Rasha Salama
Diabetes mellitus.ppt

Diabetic Retinopathy
Ines Serrano MD, Evan Waxman MD PhD
Diabetic Retinopathy.ppt

Introduction of Stem Cell Technology
Hariom Yadav etal
Introduction of Stem Cell Technology.ppt

Trends in epidemiology of type 1 diabetes mellitus
Ingrid Libman, M.D., Ph.D., Ronald LaPorte, Ph.D.
Trends in epidemiology of type 1 diabetes mellitus.ppt

Alterations of Lipid Metabolism in Diabetes Mellitus
Neile Edens, Ph.D.
Lipid Metabolism in Diabetes Mellitus.ppt

Diabetes
Ly Li Pang, Diana Jimenez, Genia Albalos
Diabetes.ppt

Juvenile Diabetes
Eric Ruggieri
Diabetes.ppt

Diabetes Mellitus
Lora Stowitzky
Diabetes.ppt

Diabetic Retinopathy
Tina Duke Salazar, Sandy Haney, Sharon Grissom
Diabetic Retinopathy.ppt

Diabetes in School
Diane Spokus
Diabetes in School.ppt

Trends in Diabetes Management
Cindy Lingle
Trends in Diabetes Management.ppt

Diabetes and Glucose Monitoring
Kayla Walker
Diabetes and Glucose Monitoring.ppt

Diabetes around the World
Diabetes.ppt

Modeling Glucose-Insulin Relationship
Jeremy Heersink
Modeling Glucose-Insulin Relationship.ppt

Diabetes Type 2
Humaira Fareed Hassan
Diabetes Type 2.ppt

Diabetes Mellitus: General information
Boston Globe
Diabetes Mellitus.ppt

Diabetes
By: Tanesha Haynes
Diabetes.ppt

Drugs Affecting the Endocrine System
Drugs Affecting the Endocrine System.ppt

Diabetes Prevention Module Health Information on the Web
Diabetes_Prevention_Handouts.ppt

Glucose Metabolism & Diabetes
Jennifer J. Darrow
Glucose Metabolism & Diabetes.ppt
50 free full text articles on Juvenie Diabetes

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Anesthesia and Analgesia Latest 600 free full text published articles



Anesthetic Management of the Patient with Preeclampsia
Dmitry Portnoy, MD
Preeclampsia .ppt

Post-Dural Puncture Headache
Dmitry Portnoy, MD
PDPH.ppt

Unsatisfactory Epidural Block for Labor Analgesia
Dmitry Portnoy, MD
LEA-Mng.ppt

Neuraxial Opioids in Obstetrics
Dmitry Portnoy, MD
Neuraxial Opioids in Obstetrics.ppt

Management of Labor Epidural: Tools of the Trade
Dmitry Portnoy, MD
Management of Labor Epidural.ppt

Labor Epidural Analgesia
Dmitry Portnoy, MD
Labor Epidural Analgesia.ppt

Total Spinal Anesthesia Following Subarachnoid Injection of Local Anesthetic for Cesarean Section
(Two Case Reports)
Dmitry Portnoy, MD
Total Spinal Anesthesia.ppt

Informed Consent in Obstetric Anesthesia
Dmitry Portnoy
Informed Consent in Obstetric Anesthesia.ppt

Complications and Side Effects of Obstetric Neuraxial Anesthesia and Analgesia
Dmitry Portnoy, MD
Complications.ppt

Aspiration
Harry Singh, MD
ASPIRATION.ppt

Anesthesia For Pediatric Spinal Surgery 
Dr Deborah Elkon
Spine.ppt

Test Taking Strategies
Ronald S. Levy, M.D.
TT.ppt

Diabetic Parturients
Harry Singh, MD
Diabetic Parturients.ppt

Non-Cardiac Surgery in Children With Congenital Heart Disease
Non-Cardiac Surgery in Children With Congenital Heart Disease.ppt

Preterm Labor
Harry Singh, MD
Preterm Labor.ppt

Preoperative Issues in Children: Premedications
Amr E. Abouleish, MD, MBA
Preoperative Issues in Children.ppt

Anesthesia for Electroconvulsive Therapy
Husong Li, M.D., Ph.D.
Anesthesia for Electroconvulsive Therapy.ppt

Techniques of Labor Analgesia
Harry Singh, MD
Techniques of Labor Analgesia.ppt

Pediatric Regional Anesthesia Caudal Anesthesia
Amr Abouleish, MD, MBA
Pediatric Regional Anesthesia Caudal Anesthesia.ppt
Latest 600 free full text published articles

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05 June 2012

Immunosuppressants



Immunosuppression in Bone Marrow Transplant
Ashley Newland, PharmD
BMT_2011.ppt

Immunosuppression for Cardiac Transplantation
Immunosuppression.ppt

Transplant Associated Thrombotic Microangiopathy (TA-TMA)
Kristen Sanfilippo MD
Transplant Associated Thrombotic Microangiopathy.ppt

Agents Which Affect the Immune Response
Dan Fernandez
Agents Which Affect the Immune Response.ppt

Immunosuppressants
Immunosuppressants.ppt

Care of the Post-OLT Patient
George Makar
CareofthePostOLTPatient.ppt

Dermatology
Pediatrics/Dermatology.ppt

Eczema Atopic Dermatitis
Eczema Atopic Dermatitis.ppt

Introduction to Transplantation  Immunosuppression
Transplantation  Immunosuppression.ppt

Organ Transplant and Recovery 
K. Brooks, RN, MSNEd
Organ Transplant and Recovery .ppt

Transplantation Immunology
Mitchell S. Cairo, MD
Transplantation Immunology.ppt

Hypersensitivity Disorders
Hypersensitivity Disorders.ppt

Thrombotic Microangiopathy after Stem Cell Transplant
Janakiraman Subramanian M.D.
Thrombotic Microangiopathy after Stem Cell Transplant.ppt

Chronic GVHD: in Search of a Model to Understand its Pathobiology
Mark A. Schroeder, M.D.
Chronic GVHD.ppt

Post PCI Contrast Induced Nephropathy
Brandon M. Williams M.D
Post PCI Contrast Induced Nephropathy.ppt

Calcium entry and calcium signaling – different routes, different roles
Calcium entry and calcium signaling.ppt

Atopic Dermatitis
Nnenna G. Agim, MD
Atopic Dermatitis.ppt

Drugs in the Therapy of Transplant Rejection
Dr. Thomas Abraham
ImmunosuppressiveAgents.ppt

Principles of Pharmacology Immunomodulators
Dr. Laure Aurelian
Principles of Pharmacology Immunomodulators.ppt

Care of Clients with Altered Immunity
Care of Clients with Altered Immunity.ppt
467 Published articles list

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Adrenal crisis



Adrenal Crisis
Nicole Wilde
Adrenal Crisis .ppt

Hypercalcemia and Multiple Myeloma
Hypercalcemia and Multiple Myeloma.ppt

Hypercalcemia secondary to Primary Hyperparathyroidism
Emily Kingsley, MD
Hypercalcemia secondary to Primary Hyperparathyroidism .ppt

Emergency Care: Addisonian Crisis & Adrenal Insufficiency
Emergency Care: Addisonian Crisis & Adrenal Insufficiency.ppt

Dehydration
Paul R. Earl
Dehydration.ppt

Primary Adrenal Disease
Briana Patterson, M.D.
Primary Adrenal Disease.ppt

Adrenal Insufficiency
C.R.Kannan, M.D.
AdrenalCortex.ppt

Hypertensive Crisis
Rozina Mithani
Hypertensive Crisis.ppt

Endocrine Disorders
Endocrine Disorders.ppt

Newborn Screening I
Ma Teresa C. Ambat, MD
newborn_screen.ppt

Disorders of Sodium and Potassium Metabolism
Disorders of Sodium and Potassium Metabolism.ppt

Endocrine – Adrenal Gland
Endocrine – Adrenal Gland.ppt

Adrenal Glands
Adrenal Glands.ppt

Adrenal Function, Testing and Disorders
Ricki Otten, MT(ASCP)SC
Adrenal Function, Testing and Disorders.ppt

Endocrine System
endocrine.ppt

Pituitary and Adrenal Stressors
Prof. Borrero
Pituitary and Adrenal Stressors.ppt

Addison’s Disease: The insufficiency of adrenal glands
Addison’s Disease.ppt

Diseases of the Endocrine Glands
Major Determinants of Disease
Diseases of the Endocrine Glands.ppt

Drugs in Dermatology
Drugs.ppt

Endocrine and Hepatic Disorders
Kimberley McComb-Meisinger RN-BC MSN
Endocrine_and_Hepatic_Disorders.ppt

Endocrine Pathology
Jodi-Ann Paragon-Singh, Jenna Pair
Endocrine Pathology.ppt

Fluid and Electrolyte Abnormalities
Fluid_and_Electrolyte_Abnormalities.ppt

Adrenal Steroids Mineralocorticoids & Glucocorticoids
Adrenal Steroids Mineralocorticoids & Glucocorticoids.ppt

Endocrine System
Endocrine System.ppt

Endocrine Physiology: Case Studies in Adrenal Disorders
C.W. Spellman, PhD, DO
EndoQuiz3.ppt

Adrenal Tumors
Mark S. Cohen, MD
Adrenal Tumors.ppt
100 Published articles list

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04 June 2012

Antithrombin Deficiency



Venous Thromboembolism
Venous Thromboembolism.ppt

Christmas  Disease
Hemophilia.ppt

PATHOPHYSIOLOGY OF THROMBOSIS
Medtech.ppt

Hypercoagulable States
Thrombosis.ppt

ADAM  Syndrome Androgen Deficiency in the Aging Man Andropause
Norman  Jensen MD MS
ADAM  Syndrome Androgen Deficiency in the Aging Man Andropause.ppt

Fibrinolysis and Thrombophilia
Fibrinolysis and Thrombophilia.ppt

Secondary Hemostasis
Secondary Hemostasis.ppt

Thrombosis:  Principles in Clinical Practice
Matthew  Bunte, MD
Thrombosis:  Principles in Clinical Practice.ppt

Hematology Emergencies
Jack Lazerson, M.D.
HematologyEmergencies.ppt


Dysfibrinogenemia and Thrombosis
Aml Girgis,MD
Dysfibrinogenemia and Thrombosis.ppt

Renal vein thrombosis
Renal vein thrombosis.ppt

Clotting  of Blood
Clotting.ppt

Protein  C and Protein S Deficiency
Paolo  Aquino
Protein  C and Protein S Deficiency.ppt

Hypercoagulable  States: Polycythemia Vera
Chris  Caulfield
Polycythemia Vera .ppt

Indications  for a thrombophilia workup in Obstetrics
Helen H. Kay,  MD
Indications  for a thrombophilia workup in Obstetrics.PPT

Atypical  Wounds 
Robert  S. Kirsner, M.D.. PhD
Atypical  Wounds.ppt
168 Full text articles list

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Purine metabolism



Nucleotides, Purine Biosynthesis and Purine Catabolism
Purine Catabolism.ppt

Clinical Pharmacology - Drug Therapy of Gout
Reginald D Sanders, MD
Gout Pharmacology.ppt

Amino Acid Biosynthesis
MetabolismIII.ppt

The biosynthetic origins of purine ring atoms
Nucleotide_metabolism.ppt

Biosynthesis of nucleotides
Natalia Tretyakova, Ph.D.
Lectures1and2.ppt

Arthritis of the Hands
Arthritis of the Hands.ppt

Immunosuppresseive agents
Dr. Prakash Nagarkatti
Immunosuppresseive agents.ppt

Non-specific immunosuppressants
Non-specific immunosuppressants.ppt

Diseases that Affect the Kidney and Urinary Tract
Nancy Long Sieber, Ph.D
Diseases that Affect the Kidney and Urinary Tract.ppt

Rhabdomyolysis
Rhabdomyolysis.ppt

renal failure in multiple myeloma
Myeloma.ppt

Metabolism of Purine and Pyrimidine Nucleotides
Metabolism of Purine and Pyrimidine Nucleotides.ppt

Lesch-Nyhan Disease
By: Lindsey Kost
Lesch-Nyhan Disease.ppt

Gout
Wayne Blount, MD, MPH
GOUT.ppt

Purine Metabolism/Diseases
Raymond B. Birge
Purine Metabolism/Diseases.ppt

74 full text articles free access

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Pyelonephritis



Renal Pathology
http://www.dent.ohio-state.edu/courses/path655/Path%20655%20Renal%20II.comp.ppt

Case Study
Tania Guevara, Anthony Edmund
http://instructional1.calstatela.edu/nmcquee/Micro302/Group%20cases/Case%201.PPT

Urinary System
http://instructional1.calstatela.edu/kkholle/384N/13)%20Urinary%20System.ppt

Urinary tract infection in children
Professor Abdelaziz Elamin
http://www.pitt.edu/~super7/43011-44001/43861.ppt

Introduction to Clinical Laboratory Practices Renal Diseases
http://colleges.weber.edu/chp/cls/clsonline/1113/Renal%20Disease.ppt

Urinary Tract Infection
Michele Ritter, M.D.
http://www9.georgetown.edu/faculty/wheltosa/Shelly_UTI.ppt

Infections of the Urinary Tract
Denise Schain MD
http://www.mgm.ufl.edu/~gulig/mmid/lectures/UTI_MMID_2011_rev.ppt

Acute Pyelonephritis
RenalPathology-Labs3,4,5.ppt

Radical Nephrectomy
PATHOLOGY-ANSWER.ppt

Diseases of the Urinary System
Diseases of the Urinary System.ppt

Chronic renal failure
Stephen P. DiBartola, DVM
Chronic renal failure.ppt

Fever During and After Childbirth
Fever During and After Childbirth.ppt

Laboratory Evaluation of Urinary Tract Infection
Dr. John R. Warren
Laboratory_Evaluation_of_Urinary_Tract_Infection_v1-_3.ppt

Staphylococcus and Micrococcus
Dr. John R. Warren
Staphylococcus_and_Micrococcus_v1-_3____.ppt

Pediatric urinary tract infection
Scott Weissman, MD
Pediatric urinary tract infection.ppt

Preterm labor
Joseph Breuner, MD
Preterm labor.ppt

Meningitis and UTI
emergency_lecture_series/Meningitis and UTI.PPT

Complement Inhibition for the Treatment of Paroxysmal Nocturnal Hemoglobinuria
Monica Bessler, MD, PhD
Complement Inhibition.ppt

UTI
Lindsay Chase MD
UTIppt

Top Ten Rules of a CPC
Clinical Pathology Conference
Lisa L. Willett, MD
Top Ten Rules of a CPC.ppt

Pediatric Urinary Tract Infections
Eddie Needham, MD, FAAFP
Pediatric Urinary Tract Infections.ppt

Empiric Treatment: Pneumonia
Empiric Treatment: Pneumonia.ppt

Urinary Disorders
Infectious Urinary Disorders
Urinary Disorders.ppt

Diseases of the Urinary and Reproductive System
Diseases of the Urinary and Reproductive System.ppt

600 Published free text articles

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Plasmapheresis



Cast Nephropathy & Plasmapheresis
Alicia Notkin
Multiple_Myeloma.ppt

Acquired Cystic Kidney Disease
Alicia Notkin
Acquired_Cystic_Renal_Disease.ppt

Molecular Mechanisms of Antidiuretic Effect of Oxytocin
Alicia Notkin
Oxytocin.ppt

Therapeutics of Autoimmune Diseases
Autoimmune_Rx_4_3_06.ppt

Clinical Pathology Conference: to plasmapheresis or not?
Bill Zaloga, DO
ToPlasmapheresisOrNot.ppt

Cold Agglutinin Disease
Daniel K. Noland MD
CAD82004.ppt

Chronic Inflammatory Polyradiculoneuropathy (CIDP)
CIDP.ppt

Blood & Blood Component Donor Selection and Collection
Bill Zaloga, D.O.
Donorselectionandcollection.ppt

Renal Disorders in Multiple Myeloma
Hematology Grand Rounds, Tom Fong, MD
Renal Disorders in Multiple Myeloma.ppt

Morbidity and Mortality Conference
Brian J. Schwender, M.D.
Morbidity and Mortality Conference.ppt

Anemia
Anemia.ppt

Cryoglobulinemia
Cryoglobulinemia.ppt

Small- Vessel Vasculitides
Small- Vessel Vasculitides.ppt

Human Lupus
Human Lupus.ppt

Coping with Changing Controlled Vocabularies
James J. Cimino, M.D., Paul D. Clayton, Ph.D.
Coping with Changing Controlled Vocabularies.ppt

Coagulation Emergencies
How to deal with/avoid a bloodbath
CoagulationEmergenciesPathology.ppt

Autoimmune Inner Ear Disease
Robert H. Stroud, M.D., Jeffery T. Vrabec, M.D.
Autoimmune-Inner-Ear.ppt

Blood Collection
Terry Kotrla, MS, MT(ASCP)
DonorBloodCollection2011.ppt

Guillain-Barre Syndrome
Lisa Rose-Jones, MD
Guillain-Barre Syndrome.ppt

Gemcitabine-induced Hemolytic Uremic Syndrome
Xiaoyi (Sherry) Hu
Gemcitabine-induced Hemolytic Uremic Syndrome.ppt
Free 200 full text articles

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Swan-Neck deformity



Wrist and Hand
WristandHand.ppt

Common Finger Injuries
Wes Bailey
Common Finger Injuries.ppt

Common Orthopaedic Injuries
Eric Bohn, DO
Common Orthopaedic Injuries.ppt

Arthritis of the Hands
Arthritis of the Hands.ppt

Systemic Lupus
Erythematosus (SLE)
Systemic Lupus.ppt

General Musculoskeletal Screening: Upper Extremities
Gregory Crovetti, M.D.
Musculoskeletal_Upper.ppt

Wrist and Hand Anatomy Review
Wrist and Hand Anatomy Review.ppt

Psoriatic Arthritis
Maggie Davis Hovda
Psoriatic Arthritis.ppt

Collagen Vascular Diseases (CVD’s)
Jimmy Buffett
Collagen Vascular Diseases.ppt

Wrist and Hand Functions of the Hand
Wrist and Hand Functions of the Hand.ppt
96 published articles

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Nasal Congestion



Nasal congestion and Rhinorrhea
Ali Sepehr
Rhinosinusitis.ppt

Treatment of Allergic Rhinitis
Priya Vasudevan
Treatment of Allergic Rhinitis.ppt

Acute and Chronic Sinusitis
A Practical Guide for Diagnosis and Treatment
Sinusitis.ppt

Pediatric Rhinosinusitis
Sarah Rodriguez, MD, Matthew Ryan, MD
Pedi-sinus-slides.ppt

Turbinate Dysfunction
Shashidhar S. Reddy, MD, MPH, Matthew Ryan, MD
Turbinate Dysfunction.ppt

Medical Management of Allergic Rhinitis
Camysha Wright, Jing Shen
Medical Management of Allergic Rhinitis.ppt

Antihistamines, Decongestants, Antitussives, and Expectorants
Resp_Antihistamines.ppt

Interferences with Ventilation
Interferences with Ventilation.ppt

Difficulty breathing
Difficulty breathing.ppt

Drugs Affecting Respiratory System
Jan Bazner-Chandler MSN, CNS, RN, CPNP
Drugs Affecting Respiratory System.ppt

Drugs for Allergic Rhinitis, Cough, and Colds
Drugs for Allergic Rhinitis, Cough, and Colds.ppt

Allergic Rhinitis in Children
Dr. KANUPRIYA CHATURVEDI
Allergic Rhinitis in Children.ppt

Probiotics and Allergy
Shalini Jain , Hariom Yadav and PR Sinha
Probiotics and Allergy.ppt

MICROBIOLOGY OF OTITIS, SINUSITIS, AND MENINGITIS
PAUL A. GULIG, PH.D.
ot-sin-men-11.ppt

Seasonal Allergies: Antihistamines & the Future
Jacquelyn Covarrubias
AntihistaminesJC.ppt

Diseases of the Respiratory System
Diseases of the Respiratory System.ppt

Squamous papillomas of the nasal
Squamous papillomas of the nasal.ppt

Drugs for Common Upper Respiratory Infections
Drugs for Common Upper Respiratory Infections.ppt

Leukotriene Inhibitors: Uses Beyond Asthma
Duane L. Keitel
http://intmedweb.wfubmc.edu/download/leukotriene.ppt

Respiratory Drugs
Nancy Pares, RN, MSN
Respiratory Drugs.ppt

Otalgia
Otalgia.ppt

Swine Influenza
Jassma Taylor
Swine.ppt

Management of patients with upper respiratory tract disorder
Mrs. Mahdia Samaha Alkony
Management of patients.ppt

Allergic Rhinitis
Maianh Phung
Allergic Rhinitis.ppt

Understanding Influenza: A Contagious Respiratory Illness
Influenza.ppt
126 Published articles

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03 June 2012

Pioglitazone anti-diabetic drug cause 40% rise in the risk of bladder cancer



Doctors say go slow on use of diabetes drug after study sees cancer risk
Published in Times of India Dt. 3rd June, 2012

Chennai: Doctors in India are seeking restraint in the use of commonly used anti-diabetic drug pioglitazone after studies showed that it increases the risk of bladder cancer. Diabetologists in India say they are already seeing bladder cancers even among those who have been on lower dosages of the drug for two years or more.

    Piolglitazone, sold under many brand names such as Glizone and Pioz in India, is a prescription drug of the thiazolidinedione class that is used to bring down sugar levels in diabetics. Another medication in the same class, rosiglitazone, was withdrawn from the market in 2010 following studies showed increased risk of cardiovascular diseases.

    Now, a study published in the British Medical Journal has said exposure to pioglitazone for two years may more than double the risk of developing bladder cancer. The bladder cancer risk among patients taking the drug increases by about 83% compared to the rest of the population, the researchers said.

    Of the 115,727 patients in the UK who were part of the study, 470 of them were found to have bladder cancer. This would mean that one in every 250 patients taking the drug for more than two years is at increased risk for cancer.

    There has been no detailed study on the effectiveness of the drug in India. US agency found drug increased risk of cancer
    Some doctors say they are beginning to see new bladder cancer cases in people who have been taking lower doses (15mg) of the drug for two years.

    As a part of an ongoing study, Madras Diabetes Research Foundation has collected medical details of eight patients who developed bladder cancer after being prescribed pioglitazone. The patients were from Mumbai, Hyderabad, Chennai, Belgaum and Salem. “None of them had bladder cancer before they were prescribed the drug. It is possiblethateven lower dosages increase the risk in Indians,” said foundation director Dr V Mohan.

    The US Food and Drug Administration warned in June 2011 that taking pioglitazone for at least a year increased the risk of bladder cancer by at least 40%, and ordered the drug’s manufacturer to note the risk on the drug’s label. The drug is banned in some countries like France and Germany. Dr Mohan insists that the drug should be banned for new patients and those who have been on the drug should be warned about the risks.

    But some diabetologists argue that the benefits outweigh risks andthedrug has notbeen shown as the cause of bladder cancer, and the researchers themselves say that the risk applies to people who have been taking the maximum dosage -- 45mg every day -- for two years. They also add that it should be continued as no risk has been proved for those taking 15mg and 30mg. “Itisoneof the most effective drugs to bring sugar levels under control. Without this drug, the only option for the patientisinsulin,” said a senior diabetologist, refusing to be named.

    India has 61 million diabetics – a sizeable increase from 50.8 million in 2010. The International Diabetes Federation estimates that by 2030, India’s diabetes burden is expected to cross the 100 million mark as against 87 million estimated earlier.

http://www.bmj.com/rapid-response/2011/11/03/ema-bis-repetita
http://www.bmj.com/search/pioglitazone

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